期刊
NATURAL PRODUCT COMMUNICATIONS
卷 14, 期 6, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1934578X19857494
关键词
Capnella; soft coral; sesquiterpene; capgermacrene H; cytotoxicity; adult T-cell leukemia
资金
- Fujiwara Natural History Foundation [GL0070]
- [FRG0464-2017]
A new sesquiterpene, capgermacrene H (1) was isolated together with 7 other compounds, capgermacrenes A-G (2-8), from a population of soft coral Capnella imbricata collected from Mantanani Island, Sabah, Malaysia. The structure of this metabolite was elucidated based on spectroscopic data such as nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry. Capgermacrene A (2) showed potent cytotoxicity against adult T-cell leukemia, S1T cells at half-maximal inhibitory concentration of 0.79 mu g/mL.
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