期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 21, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nano.2019.102065
关键词
Liposome; Remote control; Magnetic nanoparticles; Extremely low frequency magnetic field (ELF MF); ATR-FTIR spectroscopy
资金
- Russian Foundation for Basic Research [17-54-33027, 18-29-09154]
This work presents direct evidence of disordering of liposomal membranes by magnetic nanoparticles during their exposures to non-heating alternating Extremely Low Frequency Magnetic Field (ELF MF). Changes in the lipid membrane structure were demonstrated by the Attenuated total reflection Fourier Transform Infrared and fluorescence spectroscopy. Specifically, about 50% of hydrophobic chains became highly mobile under the action of ELF MF. Magnetic field-induced increase in the membrane fluidity was accompanied by an increase in membrane permeability and release of solutes entrapped in liposomes. The effect of ELF MF on the membrane fluidity was greater in case of 70 x 12 nm magnetite nanorods adsorbed on the liposomes surface compared to liposomes with similar to 7 nm spherical MNPs embedded within lipid membranes. A physical model of this process explaining experimental data is suggested. The obtained results open new horizons for the development of systems for triggered drug release without dangerous heating and overheating of tissues. (C) 2019 Elsevier Inc. All rights reserved.
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