期刊
NANO LETTERS
卷 19, 期 7, 页码 4527-4534出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b01333
关键词
Traumatic brain injury; reactive oxygen and nitrogen species; nanozyme; catalytic selectivity
类别
资金
- National Natural Science Foundation of China [21874154, 81471786, 91859101]
- Independent Innovation Foundation of Tianjin University
Reactive oxygen and nitrogen species (RONS), especially reactive nitrogen species (RNS) are intermediate products during incidence of nervous system diseases, showing continuous damage for traumatic brain injury (TBI). Here, we developed a carbogenic nanozyme, which shows an antioxidant activity 12 times higher than ascorbic acid (AA) and behaves as multienzyme mimetics. Importantly, the nanozyme exhibits an ultrahigh scavenging efficiency (similar to 16 times higher than AA) toward highly active RNS, such as (NO)-N-center dot and ONOO- as well as traditional reactive oxygen species (ROS) including O-2(center dot-), H2O2, and (OH)-O-center dot. In vitro experiments show that neuron cells injured by H2O2 or lipopolysaccharide can be significantly recovered after carbogenic nanozyme treatment via scavenging all kinds of RONS. Moreover, the carbogenic nanozyme can serve as various enzyme mimetics and eliminate the harmful peroxide and glutathione disulfide from injured mice, demonstrating its potential as a therapeutic for acute TBI.
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