相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Design and Structural Evolution of Matrix Metalloproteinase Inhibitors
Thomas Fischer et al.
CHEMISTRY-A EUROPEAN JOURNAL (2019)
Drug Design Inspired by Nature: Crystallographic Detection of an Auto-Tailored Protease Inhibitor Template
Flavio M. Gall et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
Reducing proteolytic liability of a MMP-14 inhibitory antibody by site-saturation mutagenesis
Ki Baek Lee et al.
PROTEIN SCIENCE (2019)
Recent opportunities in matrix metalloproteinase inhibitor drug design for cancer
Yue Zhong et al.
EXPERT OPINION ON DRUG DISCOVERY (2018)
MMP-3 (-1171 5A/6A; Lys45Glu) variants affect serum levels of matrix metalloproteinase (MMP)-3 and correlate with severity of COPD: A study of MMP-3, MMP-7 and MMP-12 in a Tunisian population
Sarra Bchir et al.
JOURNAL OF GENE MEDICINE (2018)
Andecaliximab/GS-5745 Alone and Combined with mFOLFOX6 in Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Results from a Phase I Study
Manish A. Shah et al.
CLINICAL CANCER RESEARCH (2018)
Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes
Arthur Winer et al.
MOLECULAR CANCER THERAPEUTICS (2018)
The promise and challenges of immune agonist antibody development in cancer
Patrick A. Mayes et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Use of a novel camelid-inspired human antibody demonstrates the importance of MMP-14 to cancer stem cell function in the metastatic process
Kuan-Hui E. Chen et al.
Oncotarget (2018)
Cutting to the Chase: How Matrix Metalloproteinase-2 Activity Controls Breast-Cancer-to-Bone Metastasis
Marilena Tauro et al.
CANCERS (2018)
Epitope-specific affinity maturation improved stability of potent protease inhibitory antibodies
Tyler Lopez et al.
BIOTECHNOLOGY AND BIOENGINEERING (2018)
Generation of inhibitory monoclonal antibodies targeting matrix metalloproteinase-14 by motif grafting and CDR optimization
Dong Hyun Nam et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2017)
Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis
Albert G. Remacle et al.
ONCOTARGET (2017)
Anti-tumor effects of a 'human & mouse cross-reactive' anti-ADAM17 antibody in a pancreatic cancer model in vivo
Jie Ye et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9
Todd C. Appleby et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution
Valeria Arkadash et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach
Hiroshi Nara et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models
Binbing Ling et al.
ONCOTARGET (2017)
Design and discovery of novel thiazole derivatives as potential MMP inhibitors to protect against acute lung injury in sepsis rats via attenuation of inflammation and apoptotic oxidative stress
Lingqing Ge et al.
RSC ADVANCES (2017)
A phase 3 randomized, double-blind, placebo controlled study to evaluate the efficacy and safety of GS-5745 combined with mFOLFOX6 as first-line treatment in patients with advanced gastric or gastroesophageal junction adenocarcinoma.
Johanna C. Bendel et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Matrix metalloproteinases as regulators of inflammatory processes
Barbara Fingleton
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)
Identification of highly selective MMP-14 inhibitory Fabs by deep sequencing
Tyler Lopez et al.
BIOTECHNOLOGY AND BIOENGINEERING (2017)
Minimalist Antibodies and Mimetics: An Update and Recent Applications
Virginia J. Bruce et al.
CHEMBIOCHEM (2016)
The molecular biology of matrix metalloproteinases and tissue inhibitors of metalloproteinases in inflammatory bowel diseases
Magali de Bruyn et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2016)
Anti-MMP-9 Antibody: A Promising Therapeutic Strategy for Treatment of Inflammatory Bowel Disease Complications with Fibrosis
Laurence Goffin et al.
INFLAMMATORY BOWEL DISEASES (2016)
Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs
Agata Jablonska-Trypuc et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2016)
Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries
Dong Hyun Nam et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo
Kenneth A. Botkjaer et al.
ONCOTARGET (2016)
Epitope mapping by a Wnt-blocking antibody: evidence of the Wnt binding domain in heparan sulfate
Wei Gao et al.
SCIENTIFIC REPORTS (2016)
Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody
Yue Tao et al.
SCIENTIFIC REPORTS (2016)
Antiviral Therapy by HIV-1 Broadly Neutralizing and Inhibitory Antibodies
Zhiqing Zhang et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
Imbalance between matrix metalloproteinases and their tissue inhibitors in preeclampsia and gestational trophoblastic diseases
Beenish Rahat et al.
REPRODUCTION (2016)
N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity
Elisa Nuti et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy
Eleanor I. Ager et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
Matrix metalloproteinases in destructive lung disease
A. McGarry Houghton
MATRIX BIOLOGY (2015)
The role of TIMPs in regulation of extracellular matrix proteolysis
Valerie Arpino et al.
MATRIX BIOLOGY (2015)
Moving targets: Emerging roles for MMPs in cancer progression and metastasis
Gemma Shay et al.
MATRIX BIOLOGY (2015)
A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways
Jonathan Rios-Doria et al.
MOLECULAR CANCER THERAPEUTICS (2015)
Cartilage damage in osteoarthritis and rheumatoid arthritis-two unequal siblings
Thomas Pap et al.
NATURE REVIEWS RHEUMATOLOGY (2015)
Renaissance of MMPs as Therapeutic Targets? Maybe
Gregory I. Goldberg
STRUCTURE (2015)
Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody
Yael Udi et al.
STRUCTURE (2015)
Adverse Events of Monoclonal Antibodies Used for Cancer Therapy
Mei Guan et al.
BIOMED RESEARCH INTERNATIONAL (2015)
Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy
Eleanor I. Ager et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
Metalloproteinases and Wound Healing
Matthew P. Caley et al.
ADVANCES IN WOUND CARE (2015)
Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer
Derek C. Marshall et al.
PLOS ONE (2015)
Targeting matrix metalloproteinases in cancer: Bringing new life to old ideas
Jillian Cathcart et al.
GENES & DISEASES (2015)
Matrix metalloproteinases in inflammation
Liisa Nissinen et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)
Targeting Matrix Metalloproteinases: Exploring the Dynamics of the S1' Pocket in the Design of Selective, Small Molecule Inhibitors
Benjamin Fabre et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
The multifactorial role of neutrophils in rheumatoid arthritis
Helen L. Wright et al.
NATURE REVIEWS RHEUMATOLOGY (2014)
Association of Sepsis-Related Mortality with Early Increase of TIMP-1/MMP-9 Ratio
Leonardo Lorente et al.
PLOS ONE (2014)
The history of monoclonal antibody development - Progress, remaining challenges and future innovations
Justin K. H. Liu
ANNALS OF MEDICINE AND SURGERY (2014)
A monoclonal antibody targeting a highly conserved epitope in influenza B neuraminidase provides protection against drug resistant strains
Tracey M. Doyle et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
Selective Blockade of Matrix Metalloprotease-14 with a Monoclonal Antibody Abrogates Invasion, Angiogenesis, and Tumor Growth in Ovarian Cancer
Rajani Kaimal et al.
CANCER RESEARCH (2013)
An Inhibitory Antibody against Dipeptidyl Peptidase IV Improves Glucose Tolerance in Vivo
Jie Tang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Targeting a Single Function of the Multifunctional Matrix Metalloprotease MT1-MMP IMPACT ON LYMPHANGIOGENESIS
Signe Ingvarsen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP
S. A. Shiryaev et al.
ONCOGENESIS (2013)
Matrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2 BINDING STUDIES AND CRYSTAL STRUCTURE
Jyotica Batra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential
Nett A. Sela-Passwell et al.
NATURE MEDICINE (2012)
The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger
Karl Edman et al.
CHEMMEDCHEM (2011)
The first MMP in sepsis
Roosmarijn E. Vandenbroucke et al.
EMBO MOLECULAR MEDICINE (2011)
Serum MMP-8,-9 and TIMP-1 in sepsis: High serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines
Anneli Lauhio et al.
PHARMACOLOGICAL RESEARCH (2011)
Tissue inhibitors of metalloproteinases
Gillian Murphy
GENOME BIOLOGY (2011)
New Strategies for the Next Generation of Matrix-Metalloproteinase Inhibitors: Selectively Targeting Membrane- Anchored MMPs with Therapeutic Antibodies
Laetitia Devy et al.
BIOCHEMISTRY RESEARCH INTERNATIONAL (2011)
The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function
Moran Grossman et al.
BIOCHEMISTRY (2010)
The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity
Keith Brew et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2010)
The safety and side effects of monoclonal antibodies
Trevor T. Hansel et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth
Juho Suojanen et al.
CANCER BIOLOGY & THERAPY (2009)
Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis
Laetitia Devy et al.
CANCER RESEARCH (2009)
Matrix metalloproteinases as modulators of inflammation
Anne M. Manicone et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2008)
Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects
Adam R. Johnson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8)
Ana Gutierrez-Fernandez et al.
FASEB JOURNAL (2007)
A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains
Erik Martens et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2007)
Expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinases during mouse embryonic development
Li Chen et al.
REPRODUCTION (2007)
Mechanism-based profiling of enzyme families
Michael J. Evans et al.
CHEMICAL REVIEWS (2006)
Towards third generation matrix metalloproteinase inhibitors for cancer therapy
CM Overall et al.
BRITISH JOURNAL OF CANCER (2006)
Recent advances in MMP inhibitor design
JF Fisher et al.
CANCER AND METASTASIS REVIEWS (2006)
Structure and function of matrix metalloproteinases and TIMPs
H Nagase et al.
CARDIOVASCULAR RESEARCH (2006)
Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice
Bettina Hartenstein et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2006)
Conformational variability of matrix metalloproteinases: Beyond a single 3D structure
I Bertini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Matrix metalloproteinases and angiogenesis
JE Rundhaug
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2005)
Inhibitors of gelatinase B/matrix metalloproteinase-9 activity Comparison of a peptidomimetic and polyhistidine with single-chain derivatives of a neutralizing monoclonal antibody
JL Hu et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Crystal structure of the catalytic domain of MMP-16/MT3-MMP: Characterization of MT-MMP specific features
R Lang et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Modeling of enzyme-substrate complexes for the metalloproteases MMP-3, ADAM-9 and ADAM-10
S Manzetti et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2003)
Matrix metalloproteinase inhibitors (MMPIs): The beginning of phase I or the termination of phase III clinical trials
M Pavlaki et al.
CANCER AND METASTASIS REVIEWS (2003)
Strategies for MMP inhibition in cancer:: Innovations for the post-trial era
CM Overall et al.
NATURE REVIEWS CANCER (2002)
Clinical role of MMP-2/TIMP-2 imbalance in hepatocellular carcinoma
G Giannelli et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines
MG Natchus et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Crystal structure of the Stromelysin-3 (MMP-11) catalytic domain complexed with a phosphinic inhibitor mimicking the transition-state
AL Gall et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: Implications for drug design
E Gavuzzo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease
RB Heuschkel et al.
GUT (2000)