期刊
MOLECULAR ONCOLOGY
卷 13, 期 8, 页码 1623-1650出版社
WILEY
DOI: 10.1002/1878-0261.12537
关键词
circulating tumor cells; circulating tumor DNA; liquid biopsy; pancreatic cancer; pancreatic ductal adenocarcinoma; tumor-derived circulating cell-free DNA
类别
Reliable biomarkers are required to evaluate and manage pancreatic ductal adenocarcinoma. Circulating tumor cells and circulating tumor DNA are shed into blood and can be relatively easily obtained from minimally invasive liquid biopsies for serial assays and characterization, thereby providing a unique potential for early diagnosis, forecasting disease prognosis, and monitoring of therapeutic response. In this review, we provide an overview of current technologies used to detect circulating tumor cells and circulating tumor DNA and describe recent advances regarding the multiple clinical applications of liquid biopsy in pancreatic ductal adenocarcinoma.
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