期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 75, 期 -, 页码 142-147出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2015.07.015
关键词
miR-556-5p; Prostate cancer; PPP2R2A; Cell proliferation
资金
- Department of Urology, Qianfoshan Hospital Affiliated to Shandong University
The prognosis and survival rate of prostate cancer are very poor. Previous studies have shown that miR-556- 5p have emerged as important regulators in cancer cell biological processes. The role of miR-556-5p in prostate cancer remains unclear. In this study, expression of miR-556-5p in prostate cancer cell lines and tissues was upregulated. Result of MTT assays, colony formation and anchorage-independent growth assays demonstrated that overexpression of miR-556-5p promoted prostate cancer cell growth. Additionally, PPP2R2A was identified as a direct target of miR-556-5p. Ectopic expression of miR-556-5p led to downregulation of PPP2R2A protein, which resulted in the downregulation of p27, upregulation of cyclin D1. Taken together, our data provide compelling evidence that miR-556-5p functions as an onco-miRNA and participates in prostate cancer carcinogenesis by suppressing PPP2R2A expression. (C) 2015 Elsevier Masson SAS. All rights reserved.
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