期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 180, 期 -, 页码 89-96出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2019.04.004
关键词
Selenium; Selenoprotein; Parkinson's disease; Oxidative stress
资金
- Natural Science Foundation of Zhejiang Province [LD19H090001, LZ19H090002]
- National Natural Science Foundation of China [81771380, 81771510, 81571087]
- Zhejiang Provincial Medical Technology Program [2018KY120]
- Wenzhou Municipal Science and Technology Bureau [Y20170071, C20170003]
- Mississippi Agricultural and Forestry Experiment Station [MIS-384050]
Selenium (Se), an essential trace mineral, confers its physiological functions mainly through selenoproteins, most of which are oxidoreductases. Results from animal, epidemiological, and human genetic studies link Parkinson's disease to Se and certain selenoproteins. Parkinson's disease is characterized by multiple motor and non-motor symptoms that are difficult to diagnose at early stages of the pathogenesis. While irreversible, degenerative and age-related, the onset of Parkinson's disease may be delayed through proper dietary and environmental controls. One particular attribute of Se biology is that brain has the highest priority to receive and retain this nutrient even in Se deficiency. Thus, brain Se deficiency is rare; however, a strong body of recent evidence implicates selenoprotein dysfunction in Parkinson's disease. Direct and indirect evidence from mouse models implicate selenoprotein T, glutathione peroxidase 1, selenoprotein P and glutathione peroxidase 4 in counteracting Parkinson's disease through Se transportation to the brain and reduced oxidative stress. It is of future interest to further characterize the full selenoproteomes in various types of brain cells and elucidate the mechanism of their actions in Parkinson's disease.
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