期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 180, 期 -, 页码 107-116出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2019.04.005
关键词
Frailty; Frailty index; Deficit accumulation; Deficit index; Alzheimer disease; Metabolic syndrome; Cardiac ageing; Network; Resilience
资金
- Canadian Institutes of Health Research (CIHR) [PJT 156114, CIHR PJT 155961, 162462]
- Fountain Family Innovation Fund of the Queen Elizabeth II Health Sciences Foundation
With ageing, the potency of individual risk factors traditionally associated with common illnesses declines. Instead, it is becoming clear that the impact of a wide range of age-related deficits not traditionally considered as risk factors for these illnesses increases. These age-related deficits chiefly confer risk as a group, not individually. The many effects of age-related changes can be demonstrated epidemiologically, and in preclinical models, using a frailty index to distinguish between the contributions of traditional and non-traditional risk factors. Quantifying the contribution of age-related deficit accumulation in clinical and preclinical samples offers a powerful new tool for understanding mechanisms of age-related disease. It appears that a range of common late-life illnesses might be targeted by drugs aimed at ageing processes.
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