期刊
APPLIED SURFACE SCIENCE
卷 386, 期 -, 页码 269-275出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2016.05.157
关键词
Hydroxyapatite nanoparticles; Surface initiated RAFT; Surface modification; Biological imgaing; Controlled drug delivery
类别
资金
- National Science Foundation of China [51363016, 21474057, 21564006, 21561022, 21376190]
- National 973 Project [2011CB935700]
- NWU Graduate Innovation and Creativity Funds [YZZ14045]
Hydroxyapatite nanomaterials as an important class of nanomaterials, have been widely applied for different biomedical applications for their excellent biocompatibility, biodegradation potential and low cost. In this work, hydroxyapatite nanorods with uniform size and morphology were prepared through hydrothermal synthesis. The surfaces of these hydroxyapatite nanorods are covered with hydrophobic oleic acid, making them poor dispersibility in aqueous solution and difficult for biomedical applications. To overcome this issue, a simple surface initiated polymerization strategy has been developed via combination of the surface ligand exchange and reversible addition fragmentation chain transfer (RAFT) polymerization. Hydroxyapatite nanorods were first modified with Riboflavin-5-phosphate sodium (RPSSD) via ligand exchange reaction between the phosphate group of RPSSD and oleic acid. Then hydroxyl group of nHAp-RPSSD was used to immobilize chain transfer agent, which was used as the initiator for surface-initiated RAFT polymerization. The nHAp-RPSSD-poly(IA-PEGMA) nanocomposites were characterized by means of H-1 nuclear magnetic resonance, Fourier transform infrared spectroscopy, fluorescence spectroscopy and thermal gravimetric analysis in detailed. The biocompatibility, biological imaging and drug delivery of nHAp-RPSSD-poly(IA-PEGMA) were also investigated. Results showed that nHAp-RPSSD-poly(IA-PEGMA) exhibited excellent water dispersibility, desirable optical properties, good biocompatibility and high drug loading capability, making them promising candidates for biological imaging and controlled drug delivery applications. (C) 2016 Elsevier B.V. All rights reserved.
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