期刊
MATERIALS LETTERS
卷 245, 期 -, 页码 158-161出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2019.02.104
关键词
Semiconductors; Functional; Light-harvesting; Photothermal conversion; Drug loading
资金
- Natural Science Foundation of Henan Province [162300410212, 81801750]
- Natural Science Foundation of China [162300410212, 81801750]
- Key Research Project of Colleges and Universities of Henan Province [17B150008, 19A150006]
- Science and Technology Key Projects of Xinxiang City [CXGG17004]
- Doctoral Startup Fund of Xinxiang Medical University [XYBSKYZZ201509]
Metal chalcogenide semiconductor nanomaterials are emerging as a promising photothermal and theranostic agent. In this work, uniform Bi2S3 hollow spheres (HS) have been successfully synthesized by using glycerol (Gly) and polyvinylpyrrolidone (PVP) as morphology regulator, and L-cysteine (L-Cys) as a sulfur source and surface modifier. The resulting L-Cys/Bi2S3 HS shows a stronger near-infrared (NIR) harvesting capability in comparison with its solid counterpart, and the photothermal conversion efficiency reached up to 31.5%. The nature of hollow structure endows the L-Cys/Bi2S3 HS with higher specific surface area and enhanced drugs loading capacity. As high as 86.4% doxorubicin (DOX) could be loaded to the outer and inner surfaces of L-Cys/Bi2S3 HS and their controlled releasing behavior follow a pH- and time-dependent manner. Meanwhile, the functional group of L-cysteine imparted the HS with good dispersibility and biocompatibility. The novel hollow materials with simultaneous integrated photothermal ablation and drug therapy may be a promising agent for cancer treatment. (C) 2019 Elsevier B.V. All rights reserved.
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