期刊
MARINE DRUGS
卷 17, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/md17060332
关键词
Aspergillus terreus YPGA10; deep-sea-derived fungus; butenolide derivatives; alpha-glucosidase
资金
- National Key R&D Program of China [2017YFD0600702-2]
- China Ocean Mineral Resources R&D Association (COMRA) Program [DY135-B2-09]
- First-Class Discipline Construction Project of Henan University [2018YLZDCG03]
- China Postdoctoral Science Foundation [2018M630815]
- Henan University [B2017067]
Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1-3 were determined on the basis of comprehensive analyses of the nuclear magnetic resonance (NMR) and mass spectroscopy (MS) data, and the absolute configurations of 1 and 2 were determined by comparisons of experimental electronic circular dichroism (ECD) with calculated ECD spectra. Compound 1 represents the rare example of Aspergillus-derived butenolide derivatives featured by a monosubstituted benzene ring. Compounds 6-9 exhibited remarkable inhibitory effects against alpha -glucosidase with IC50 values of 3.87, 1.37, 6.98, and 8.06 mu M, respectively, being much more active than the positive control acarbose (190.2 mu M).
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