期刊
MARINE DRUGS
卷 17, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/md17070416
关键词
spongian furanoditerpenes; marine sponge; Spongia tubulifera; ECD-TDDFT; cytotoxicity
资金
- AEI/FEDER, EU from the State Agency for Research (AEI) of Spain [AGL2015-63740-C2-2-R, RTC-2016-4611-1]
- FEDER Programme from the European Union
- National Council of Science and Technology (CONACYT) of Mexico
- Secretariat of Research, Innovation and Higher Education (SIIES) of Yucatan (Mexico)
Two new spongian furanoditerpenes, 3 beta-hydroxyspongia-13(16),14-dien-2-one (1) and 19-dehydroxy-spongian diterpene 17 (2), along with five known terpenes, the spongian furanoditerpenes 9-nor-3-hydroxyspongia-3,13(16),14-trien-2-one (3), 3 beta,19 dihydroxyspongia-13(16),14-dien-2-one (epispongiadiol) (4) and spongian diterpene 17 (5), the furanoditerpene ambliol C (6), and the sesterterpene scalarin (7), were isolated from the methanolic extract of the sponge Spongia tubulifera, collected in the Mexican Caribbean. The planar structures of the new compounds were elucidated by 1D/2D NMR and IR spectroscopic analysis, high resolution electrospray mass spectrometry (HRESIMS), and comparison of their spectral data with those reported in the literature. Absolute configurations were determined by comparison of the experimental electronic circular dichroism (ECD) spectrum with those calculated by time-dependent density functional theory (TDDFT). Compounds 1, 4, and 6 displayed weak cytotoxic activity against different human tumour cell lines.
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