期刊
MARINE DRUGS
卷 17, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/md17060322
关键词
marine-derived fungus; Penicillium sp; HK1-22; naphtho-gamma-pyrones; antibacterial activity; antifungal activity
资金
- National Natural Science Foundation of China [81703411, 41830535, U1606403, 41776156]
- Marine S & T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao) [2018SDKJ0406-5]
- National Science and Technology Major Project for Significant New Drugs Development [2018ZX09735-004]
- Program of Open Studio for Druggability Research of Marine Natural Products
- Pilot National Laboratory for Marine Science and Technology (Qingdao, China)
- Taishan Scholars Program, China
Three novel monomeric naphtho-gamma -pyrones, peninaphones A-C (compounds 1-3), along with two known bis-naphtho-gamma -pyrones (compounds 4 and 5) were isolated from mangrove rhizosphere soil-derived fungus Penicillium sp. HK1-22. The absolute configurations of compounds 1 and 2 were determined by electronic circular dichroism (ECD) spectra, and the structure of compound 3 was confirmed by single-crystal X-ray diffraction analysis. Compounds 4 and 5 are a pair of hindered rotation isomers. A hypothetical biosynthetic pathway for the isolated monomeric and dimeric naphtho-gamma -pyrones is also discussed in this study. Compounds 1-3 showed antibacterial activity against Staphylococcus aureus (ATCC 43300, 33591, 29213, and 25923) with minimum inhibitory concentration (MIC) values in the range of 12.5-50 mu g/mL. Compound 3 exhibited significant activity against the rice sheath blight pathogen Rhizoctonia solani.
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