期刊
MARINE DRUGS
卷 17, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/md17060334
关键词
anthraquinone derivatives; Sporendonema casei; marine-derived fungus; cytotoxic activities; antibacterial activities
资金
- National Natural Science Foundation of China [41806167, 41606166]
- Marine S&T Fund of Shandong Province for the Pilot National Laboratory for Marine Science and Technology (Qingdao) [2018SDKJ0401-2]
- Fundamental Research Funds for the Central Universities [201941001]
- Taishan Scholar Youth Expert Program in Shandong Province [tsqn201812021]
Five new anthraquinone derivatives, auxarthrols D-H (1-5), along with two known analogues (6-7), were obtained from the culture of the marine-derived fungus Sporendonema casei. Their structures, including absolute configurations, were established on the basis of NMR, HRESIMS, and circular dichroism (CD) spectroscopic techniques. Among them, compound 4 represents the second isolated anthraquinone derivative with a chlorine atom, which, with compound 6, are the first reported anthraquinone derivatives with anticoagulant activity. Compounds 1 and 3 showed cytotoxic activities with IC50 values from 4.5 mu M to 22.9 mu M, while compounds 1, 3-4, and 6-7 showed promising antibacterial activities with MIC values from 12.5 mu M to 200 mu M. In addition, compound 7 was discovered to display potential antitubercular activity for the first time.
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