期刊
MARINE DRUGS
卷 17, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/md17060347
关键词
Streptomyces; polycyclic polyether; marine sediment; X-ray diffraction; antibiotic; metabolomics
资金
- Natural Sciences and Engineering Council of Canada (NSERC)
- Canada Research Chair Program
- Atlantic Canada Opportunities Agency
- Canada Foundation for Innovation
- Nautilus Biosciences Croda
- Innovation PEI
- Jeanne and Jean-Louis Levesque Foundation
Terrosamycins A (1) and B (2), two polycyclic polyether natural products, were purified from the fermentation broth of Streptomyces sp. RKND004 isolated from Prince Edward Island sediment. The one strain-many compounds (OSMAC) approach coupled with UPLC-HRMS-based metabolomics screening led to the identification of these compounds. The structure of 1 was determined from analysis of NMR, HRMS, and X-ray diffraction data. NMR experiments performed on 2 revealed the presence of two methoxy groups replacing two hydroxy groups in 1. Like other polyether ionophores, 1 and 2 exhibited excellent antibiotic activity against Gram-positive pathogens. Interestingly, the terrosamycins also exhibited activity against two breast cancer cell lines.
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