期刊
MARINE DRUGS
卷 17, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/md17060375
关键词
marine sponges; natural compounds; bisabolane-related compounds; bioactivity; obesity; whole small animal models
资金
- European Union [607786]
- European ERA-NET Marine Biotechnology project CYANOBESITY [ERA-MBT/0001/2015]
- national funds through FCT (Foundation for Science and Technology, Portugal)
- RANNIS (Icelandic Center of Research, Iceland)
- FCT [UID/Multi/04423/2019, SFRH/BPD/112287/2015]
- Fundação para a Ciência e a Tecnologia [ERA-MBT/0001/2015, SFRH/BPD/112287/2015] Funding Source: FCT
The previously reported 1-(2,4-dihydroxy-5-methylphenyl)ethan-1-one (1), (1'Z)-2-(1',5'-dimethylhexa-1',4'-dieny1)-5-methylbenzene-1,4-diol (2), and 1,8-epoxy-1(6),2,4,7,10-bisaborapentaen-4-ol (5) together with four new structures of aromatic bisabolane-related compounds (3, 4, 6, 7) were isolated from the marine sponge Myrmekioderma sp. Compounds 1, 2, and 5 were identified based on spectral data available in the literature. The structures of the four new compounds were experimentally established by 1D and 2D-NMR and (-)-HRESIMS spectral analysis. Cytotoxic and lipid-reducing activities of the isolated compounds were evaluated. None of the isolated compounds were active against the tested cancer cell lines; however, lipid-reducing activity was found for compounds 2-5 and 7 in the zebrafish Nile red fat metabolism assay. This class of compounds should be further explored for their suitability as possible agents for the treatment of lipid metabolic disorders and obesity.
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