期刊
MARINE DRUGS
卷 17, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/md17070398
关键词
sponge-derived fungus; Penicillium sp; alkaloid; X-ray single crystal diffraction; antibacterial; cytotoxic activity
资金
- National Key Research and Development Program of China [2018YFC0310900]
- National Natural Science Foundation of China [21172230, 21502204, 21672084, 21772210, 31270402, 41476135, 41776169, 41876145]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA11030403]
- Guangdong Province PublicWelfare Research and Capacity Building Project [2016A020222010]
- Pearl River S&T Nova Program of Guangzhou [201710010136]
The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1-21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR-ESI-MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC50 value of 5.19 mu M. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 mu g/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 mu g/mL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据