期刊
LIVER INTERNATIONAL
卷 39, 期 9, 页码 1713-1721出版社
WILEY
DOI: 10.1111/liv.14161
关键词
cognitive performance; liver fibrosis; NAFLD fibrosis score; non-alcoholic fatty liver disease
资金
- NHLBI NIH HHS [N01 HC025195, HHSN268201500001I] Funding Source: Medline
- NIA NIH HHS [U01 AG052409, R01 AG033193, R01 AG049607, RF1 AG059421, U01 AG049505, P30 AG010129, R01 AG054076] Funding Source: Medline
- NINDS NIH HHS [UH3 NS100605, R01 NS017950] Funding Source: Medline
Background Non-alcoholic fatty liver disease (NAFLD) is common and has been recently related to brain health. We aimed to assess the relationships of NAFLD and its severity, using the NAFLD fibrosis score (NFS), with cognitive performance. Methods Framingham study Offspring and 3rd generation participants were included if they attended exams 9 (2002-2008) and 2 (2008-2011), respectively, were free of dementia and stroke, and did not have excessive alcohol intake. Between 2008 and 2011, participants underwent Multi-detector computed tomography scans of the abdomen to determine NAFLD diagnosis and the NFS was used to categorize the severity of fibrosis. Cross-sectional relationships of NAFLD and the NFS with cognitive testing of memory, abstract reasoning, visual perception, attention and executive function were assessed, while adjusting for multiple cardiometabolic variables including visceral adipose tissue, diabetes and insulin resistance. Results Of the 1287 participants (mean age = 61 +/- 12 years, 48% men), 378 (29%) had NAFLD. The presence of NAFLD was not associated with cognitive function. However, among those with NAFLD (mean age = 61 +/- 12 years; 58% men), high compared to low risk of advanced fibrosis was associated with poorer performance on similarities (beta = -2.22 +/- 0.83; P = 0.009) and trail-making B minus A (beta = -0.11 +/- 0.05; P = 0.028), independently of potential confounders. Conclusions Participants with high risk of advanced fibrosis may have poorer cognitive function compared to those with low risk, particularly in executive function and abstract reasoning. Future findings are necessary to evaluate the value of the NFS as a biomarker that predicts cognitive impairment and dementia and to explore the role of hepatic fibrosis in brain health.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据