期刊
LANGMUIR
卷 35, 期 26, 页码 8799-8805出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.9b01325
关键词
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资金
- National Natural Science Foundation of China [21775075]
- Fundamental Research Funds for Central Universities (China)
- Thousand Youth Talents Plan of China
Preventing protein corona formation and macrophage uptake is the key to improving the delivery efficiency of nanocarriers. Herein, we present a kind of cross-linking poly(ethylene glycol) (CL-PEG) shell-wrapped gold nanoparticles (namely, Au@CL-PEG NPs), which show much enhanced stealth effect and colloidal stability in physiological environments. Compared to the AuNPs coated with conventional linear PEGs (namely, Au@PEG NPs), AugCL-PEG NPs have a greater ability to resist protein adsorption and thus show reduced cellular uptake by macrophages. In addition, the AugCL-PEG NPs show higher chemical and colloidal stability under different extreme conditions than the conventional Au@PEG NPs. The CL-PEGylation strategy provides a new window for the surface functionalization of nanomaterials, indicating great promise for the development of high-performance nanomedicines.
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