期刊
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
卷 158, 期 6, 页码 1710-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jtcvs.2019.06.058
关键词
living-donor lobar lung transplantation; pulmonary function; forced vital capacity; forced expiratory volume in 1 second; computed tomography volumetry
Objective: In standard bilateral living-donor lobar lung transplantation (LDLLT), the right and left lower lobes from 2 healthy donors are implanted in the recipient in place of whole right and left lungs. In other words, total 10 lobes (5 lobes in each donor) are shared by the 2 donors (4 lobes in each donor) and the recipient (2 lobes) in this transplant procedure. This study aimed to compare pulmonary function between donors and recipients before and after LDLLT. Methods: We performed 76 LDLLT procedures between June 2008 and March 2017. After excluding 12 single LDLLT and 11 native-lung-sparing LDLLT procedures, we identified 38 recipients of bilateral LDLLTwho survived>1 year and underwent routine pulmonary function testing. Acquired recipient pulmonary function was compared with lost donor pulmonary function at 1 year post-LDLLT. Results: The median age of the 38 recipients was 44 years (range, 8-62 years); 14 were men. The median age of the 76 donors was 41.5 years (range, 20-60 years); 50 were men. One year post-LDLLT, acquired recipient forced vital capacity was significantly greater than lost donor forced vital capacity (1889.5 +/- 581.3 mL vs 1073.9 +/- 661.6 mL; P<.001). Similarly, acquired recipient forced expiratory volume in 1 second at 1 year post-LDLLT was significantly greater than lost donor forced expiratory volume in 1 second (1646.8 +/- 483.0 mL vs 1064.2 +/- 534.5 mL; P<.001). Conclusions: These results indicated that acquired recipient pulmonary function was better than lost donor pulmonary function in bilateral LDLLT.
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