期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 31, 页码 12202-12206出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b05261
关键词
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资金
- European Research Council [ERC AdG 692775]
- Planning and Budgeting Committee (PBC)
- Weizmann Institute of Science and Koshland Foundation
Amide synthesis is one of the most important transformations in chemistry and biology. The direct use of ammonia for the incorporation of nitrogen functionalities in organic molecules is an attractive and environmentally benign method. We present here a new synthesis of amides by acceptorless dehydrogenative coupling of benzyl alcohols and ammonia. The reaction is catalyzed by a pincer complex of earth-abundant manganese in the presence of a stoichiometric base, making the overall process economical, efficient, and sustainable. Interesting mechanistic insights based on detailed experimental observations, indicating the crucial role of the base, are provided.
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