期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 23, 页码 9391-9400出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b03991
关键词
-
资金
- Indiana University
- NIH [R01GM114443, R35GM128779]
- Vice Provost for Research through the Research Equipment Fund
- NSF [CHE1726633]
- NSF
A method for the Ni-catalyzed arylboration of unactivated monosubstituted, 1,1-disubstituted, and trisubstituted alkenes is disclosed. The reaction is notable in that it converts highly substituted alkenes, aryl bromides, and diboron reagents to products that contain a quaternary carbon and a synthetically versatile carbon boron bond with control of stereoselectivity and regioselectivity. In addition, the method is demonstrated to be useful for the synthesis of saturated nitrogen heterocycles, which are important motifs in pharmaceutical compounds. Finally, due to the unusual reactivity demonstrated, the mechanistic details of the reaction were studied with both computational and experimental techniques.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据