期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 25, 页码 9813-9818出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b04606
关键词
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资金
- National Science Foundation [CHE-1665389]
- NIH [S10OD011952]
Here we disclose a cascade strategy for naphthyne formation that capitalizes on the traditional benzyne generation (i.e., from an ortho-silyl aryl triflate) and the thermal hexadehydro-Diels-Alder (HDDA) reaction. In this transformation, three distinct aryne species work in tandem, two of which can be formally considered as a 1,2-benzidyne, and each undergoes a different type of trapping event. Many examples were explored by varying the naphthyne capture chemistry as well as the 1,2-benzdiyne equivalent. This strategy enables rapid construction of various naphthalene products and has potential for the synthesis of extended polycyclic arenes.
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