期刊
JOURNAL OF SEPARATION SCIENCE
卷 42, 期 19, 页码 3119-3125出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201900438
关键词
magnetic graphene composites; magnetic solid-phase extraction; mainstream cigarette smoke; tobacco-specific N-nitrosamines
资金
- NationalNatural Science Foundation ofChina [21407034]
- Science Innovation Foundation ofChinaNational Tobacco Quality and Supervision Test Center [512018CA0050]
Tobacco-specific N-nitrosamines are carcinogenic components in mainstream cigarette smoke. To explore tobacco-specific N-nitrosamine release levels in cigarettes, a magnetic solid-phase extraction procedure using magnetic graphene composite as sorbent for fast enrichment of tobacco-specific N-nitrosamine was developed. Under optimal conditions, a tobacco-specific N-nitrosamine determination method was successfully proposed by combining magnetic solid-phase extraction procedure and high-performance liquid chromatography coupled with tandem mass spectrometry. The method's limit of detection for tobacco-specific N-nitrosamines in mainstream cigarette smoke ranged from 0.018 to 0.057 ng/cigarette. Good linearities were obtained with correlation coefficients above 0.9992. The accuracies of tobacco-specific N-nitrosamines in a spiked mainstream cigarette smoke sample were from 89.3 to 109.4%, with a relative standard deviation of less than 11.2%. The proposed method has the merits of rapidity and high sensitivity. Finally, the method was successfully applied to tobacco-specific N-nitrosamine analysis in real samples.
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