期刊
JOURNAL OF PROTEOME RESEARCH
卷 18, 期 10, 页码 3539-3554出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jproteome.9b00301
关键词
gut microbiota; dysbiosis; microbiome; metaproteomics; protein function; human
资金
- Egyptian Cancer Network, USA (ECN)
- Children's Cancer Hospital Egypt [57357]
During the last decade, metaproteomics has provided a better understanding and functional characterization of the microbiome. A large body of evidence now reveals interspecies, species of bacteria host interactions, via the secreted modulatory microbial protein metaproteome. Although high-throughput state-of-art mass spectrometry has recently empowered metaproteomics, its profile remains unclear, and, most importantly, the exact consequences and underlying mechanism of these protein molecules on the host are insufficiently understood. Here we address the current progress in the study of the human metaproteome, suggesting possible modulation, a metaproteome dysbiotic signature, challenges, and future perspectives.
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