期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 19, 页码 12626-12631出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b01270
关键词
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资金
- Guangdong MEPP Funds [GDME-2018C010, GDOE[2019]A28, 2019-017]
- National Natural Science Foundation of China [81673677, 21772210]
- Drug Innovation Major Project of China [2018ZX09735001-002-003]
- Institution of South China Sea Ecology and Environmental Engineering, CAS [ISEE2018PY04]
Iakyricidins A-D (1-4), a carbonyl-containing piericidin derivative and three novel piericidin analogues bearing cyclic skeletons, were isolated from the mangrove sediment derived strain Streptomyces iakyrus SCSIO NS104. These structures were established by spectroscopic techniques, Moshers method, and ECD calculations. Compounds 2-4 represent a novel skeleton of piericidins with branched chain C-C cyclization, and their biosynthetic pathways are proposed. Compound 1, the first natural carbonyl-containing piericidin derivate, exhibited potent antiproliferative activity against ACHN with an IC50 value of 20 nM.
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