期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 13, 页码 8766-8770出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b01076
关键词
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资金
- NNSFC [21625201, 21661140001, 91853202, 21521003]
- National Key Research and Development Program of China [2017YFA0505200]
- National High Technology Project 973 [2015CB856200]
The first total syntheses of chaetoglines C-F via a bioinspired and divergent synthetic strategy are reported. Chaetolines C and D were obtained from the condensation of hemiacetal and tryptophan methyl ester building blocks followed by functional group transformations. The synthesis of chaetogline E employed the diastereoselective Pictet-Spengler reaction, and the tetrahydro-carboline skeleton was further utilized as a precursor for an oxidative aromatization reaction to introduce the beta-carboline moiety of chaetogline F.
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