期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 16, 页码 10209-10220出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b01268
关键词
-
资金
- National Postdoctoral Program for Innovative Talents of China [BX201700030]
- China Postdoctoral Science Foundation [2017 M620630]
The present paper reports a highly stereoselective synthesis of spirooxindole-fused spiropyrazolones through the asymmetric [3 + 2] cyclization reaction of 2-(1-methyl-2-oxoindolin-3-yl)malononitriles with unsaturated pyrazolones under mild conditions. With only a 1 mol % bifunctional squaramide catalyst, a series of chiral dispirocyclic pyrazolone derivatives were attained in high yields (85-97%) with excellent stereoselectivities (up to >99% ee and in all cases >20:1 dr). Moreover, gram-scale synthesis and further transformation of the products were also demonstrated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据