期刊
JOURNAL OF NEUROSCIENCE
卷 39, 期 34, 页码 6696-6713出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0827-19.2019
关键词
mammillary bodies; MRI; paradoxical sleep; phase-amplitude coupling; rat; theta
资金
- Wellcome Trust [090954/Z/09/Z, 102409/Z/13/A, 212273/Z/18/Z]
- Science Foundation Ireland [SFI 13/IA/2014]
- BBSRC [BB/M021408/1] Funding Source: UKRI
- Wellcome Trust [090954/Z/09/Z, 102409/Z/13/A, 212273/Z/18/Z] Funding Source: Wellcome Trust
Diencephalic amnesia can be as debilitating as the more commonly known temporal lobe amnesia, yet the precise contribution of diencephalic structures to memory processes remains elusive. Across four cohorts of male rats, we used discrete lesions of the mammillothalamic tract to model aspects of diencephalic amnesia and assessed the impact of these lesions on multiple measures of activity and plasticity within the hippocampus and retrosplenial cortex. Lesions of the mammillothalamic tract had widespread indirect effects on hippocampocortical oscillatory activity within both theta and gamma bands. Both within-region oscillatory activity and cross-regional synchrony were altered. The network changes were state-dependent, displaying different profiles during locomotion and paradoxical sleep. Consistent with the associations between oscillatory activity and plasticity, complementary analyses using several convergent approaches revealed microstructural changes, which appeared to reflect a suppression of learning-induced plasticity in lesioned animals. Together, these combined findings suggest a mechanism by which damage to the medial diencephalon can impact upon learning and memory processes, highlighting an important role for the mammillary bodies in the coordination of hippocampocortical activity.
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