期刊
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
卷 90, 期 12, 页码 1338-1346出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jnnp-2018-319586
关键词
-
资金
- agency Flanders Innovation & Entrepreneurship
- Opening the Future Fund (KU Leuven)
- Belgian Federal Science Policy Office [P7/16]
- Flemish Government initiated Flanders Impulse Programme on Networks for Dementia Research
- European Union Joint Programme-N eurodegenerative Disease Research project STRENGTH
- RiMod-FTD, the European E-Rare-2 project PYRAMID
- Research Foundation-Flanders [11E6319N]
- Rotary's 'Espoir en Tete-Hoofd zaak er is Hoop'
- Research Foundation-Flanders (FWO-Vlaanderen) [1165119N]
- FWO-Vlaanderen
- ALS Liga Belgium
- KU Leuven ALS fund 'Een hart voor ALS'
- 'Laeversfonds voor ALS onderzoek'
Objective Inflammation is a key pathological hallmark in amyotrophic lateral sclerosis (ALS), which seems to be linked to the disease progression. It is not clear what the added diagnostic and prognostic value are of inflammatory markers in the cerebrospinal fluid (CSF) of patients with ALS. Methods Chitotriosidase-1 (CHIT1), chitinase-3-like protein 1 (YKL-40) and monocyte chemoattractant protein-1 (MCP-1) were measured in CSF and serum of patients with ALS (n=105), disease controls (n=102) and patients with a disease mimicking ALS (n=16). The discriminatory performance was evaluated by means of a receiver operating characteristic curve analysis. CSF and serum levels were correlated with several clinical parameters. A multivariate Cox regression analysis, including eight other established prognostic markers, was used to evaluate survival in ALS. Results In CSF, CHIT1, YKL-40 and MCP-1 showed a weak discriminatory performance between ALS and ALS mimics (area under the curve: 0.79, p<0.0001; 0.72, p=0.001; 0.75, p=0.001, respectively). CHIT1 and YKL-40 correlated with the disease progression rate (rho=0.28, p=0.009; rho=0.34, p=0.002, respectively). CHIT1 levels were elevated in patients with a higher number of regions displaying motor neuron degeneration (one vs three regions: 4248 vs 13 518 pg/mL, p = 0.0075). In CSF, YKL-40 and MCP-1 were independently associated with survival (HR: 29.7, p=0.0003; 6.14, p=0.001, respectively). Conclusions Our findings show that inflammation in patients with ALS reflects the disease progression as an independent predictor of survival. Our data encourage the use of inflammatory markers in patient stratification and as surrogate markers of therapy response in clinical trials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据