期刊
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
卷 90, 期 12, 页码 1347-1352出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jnnp-2018-320199
关键词
-
资金
- National Natural Science Foundation of China [81573148, 81874261]
Objective Our study aimed to assess the effect of a 12-month vitamin D supplementation on cognitive function and amyloid beta (A beta)-related biomarkers in subjects with Alzheimer's disease (AD). Methods This was a randomised, double-blind, placebo-controlled trial. 210 AD patients were randomly divided into intervention and control groups. Participants received 12-month 800 IU/day of vitamin D or starch granules as placebo. Tests of cognitive performance and A beta-related biomarkers were measured at baseline, 6 months and 12 months. Results Repeated-measures analysis of variance showed significant improvements in plasma A beta 42, APP, BACE 1, APPmRNA, BACE 1 mRNA (p<0.001) levels and information, arithmetic, digit span, vocabulary, block design and picture arrange scores (p<0.05) in the intervention group over the control group. According to mixed-model analysis, vitamin D group had significant increase in full scale IQ during follow-up period (p<0.001). Conclusions Daily oral vitamin D supplementation (800 IU/day) for 12 months may improve cognitive function and decrease A beta-related biomarkers in elderly patients with AD. Larger scale longer term randomised trials of vitamin D are needed.
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