4.7 Article

A detrimental role of RelB in mature oligodendrocytes during experimental acute encephalomyelitis

期刊

JOURNAL OF NEUROINFLAMMATION
卷 16, 期 -, 页码 -

出版社

BMC
DOI: 10.1186/s12974-019-1548-7

关键词

EAE; Inflammation; RelB; Oligodendrocytes; Astrocytes; NF-kappa B

资金

  1. NIH [R21NS100698, R21NS102802, R01AI093718, F30CA203447]
  2. Intramural Research Program of the NIAID/NIH
  3. NIH-NCI Cancer Center Support Grant [P30 CA016059]
  4. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI000722] Funding Source: NIH RePORTER

向作者/读者索取更多资源

BackgroundMultiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). It is firmly established that overactivation of the p65 (RelA) nuclear factor kappa B (NF-kappa B) transcription factor upregulates expression of inflammatory mediators in both immune and non-immune resident CNS cells and promotes inflammation during MS. In contrast to p65, NF-kappa B family member RelB regulates immune cell development and can limit inflammation. Although RelB expression is induced during inflammation in the CNS, its role in MS remains unknown.MethodsTo examine the role of RelB in non-immune CNS cells, we generated mice with RelB specifically deleted in astrocytes (RelB(Delta AST)), oligodendrocytes (RelB(Delta OLIGO)), or neural progenitor-derived cells (RelB(Delta NP)). We used experimental autoimmune encephalomyelitis (EAE), an accepted mouse model of MS, to assess the effect of RelB deletion on disease outcomes and performed analysis on the histological, cellular, and molecular level.ResultsDespite being a negative regulator of inflammation, conditional knockout of RelB in non-immune resident CNS cells surprisingly decreased the severity of EAE. This protective effect was recapitulated by conditional deletion of RelB in oligodendrocytes but not astrocytes. Deletion of RelB in oligodendrocytes reduced disease severity, promoted survival of mature oligodendrocytes, and correlated with increased activation of p65 NF-kappa B.ConclusionsThese findings suggest that RelB fine tunes inflammation and cell death/survival during EAE. Importantly, our data points out the detrimental role RelB plays in controlling survival of mature oligodendrocytes, which could be explored as a viable option to treat MS in the future.

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