期刊
JOURNAL OF NEUROIMAGING
卷 29, 期 6, 页码 699-706出版社
WILEY
DOI: 10.1111/jon.12657
关键词
Myelin water atlas; brain; myelin water fraction; white matter; multiple sclerosis
资金
- Multiple Sclerosis Society of Canada
- Natural Sciences and Engineering Research Council Discovery Grant
- General Electric (GE) Healthcare
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- Roche
- Genzyme
- Vancouver Coastal Health Research Institute
- Milan & Maureen Ilich Foundation
- Natural Sciences and Engineering Research Council of Canada
- Michael Smith Foundation for Health Research
- Canadian Institutes for Health Research
- Provincial Health Services of Authority of British Columbia
- Mind Foundation of British Columbia
- Yeung Foundation of Hong Kong
- British Columbia Children's Hospital Research Institute
- Canada Research Chairs
- Natural Sciences and Engineering Research Council
- National MS Society
- Canadian Institute of Health Research
- Merck-Serono
- Novartis
- Biogen
- Canadian Institutes of Health Research [CIHR MOP 13026, CIHR MOP 130269]
- Natural Sciences and Engineering Research Council [RPGN 04154]
BACKGROUND AND PURPOSE Myelin water imaging (MWI) is a magnetic resonance imaging technique that quantifies myelin in-vivo. Although MWI has been extensively applied to study myelin-related diseases in groups, clinical use in individual patients is challenging mainly due to population heterogeneity. The purpose of this study was twofold: (1) create a normative brain myelin water atlas depicting the population mean and regional variability of myelin content; and (2) apply the myelin atlas to assess the degree of demyelination in individuals with multiple sclerosis (MS). METHODS 3T MWI was performed on 50 healthy adults (25 M/25 F, mean age 25 years [range 17-42 years]). The myelin water atlas was created by averaging coregistered myelin water fraction (MWF) maps from all healthy individuals. To illustrate the preliminary utility of the atlas, white matter (WM) regional MWF variations were evaluated and voxel-wise z-score maps (z < -1.96) from the MWI of three MS participants were produced to assess individually the degree of demyelination. RESULTS The myelin water atlas demonstrated significant MWF variation across control WM. No significant MWF differences were found between male and female healthy participants. MS z-score maps revealed diffuse regions of demyelination in the two participants with Expanded Disability Status Scale (EDSS) = 2.0 but not in the participant with EDSS = 0. CONCLUSIONS The myelin water atlas can be used as a reference (URL: ) to demonstrate areas of demyelination in individual MS participants. Future studies will expand the atlas age range, account for education, and other variables that may affect myelination.
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