期刊
JOURNAL OF NEURO-ONCOLOGY
卷 144, 期 1, 页码 53-63出版社
SPRINGER
DOI: 10.1007/s11060-019-03215-x
关键词
Rare tumors; Incidence; Survival; Prevalence; CNS tumors
资金
- Centers for Disease Control and Prevention (CDC) [2016-M-9030]
- American Brain Tumor Association
- Sontag Foundation
- Novocure
- Musella Foundation
- National Brain Tumor Society
- Zelda Dorin Tetenbaum Memorial Fund
- National Cancer Institute (NCI) [HHSN261201800176P]
- Uncle Kory Foundation
- Cancer Prevention and Research Institute of Texas (CPRIT) [RP160097T]
- AbbVie
- NATIONAL CANCER INSTITUTE [ZIABC011768] Funding Source: NIH RePORTER
PurposePopulation-based cancer statistics, including histology-specific incidence, prevalence, and survival are essential to evaluating the total burden due to disease in a population. The National Cancer Institute's (NCI) Comprehensive Oncology Network Evaluating Rare CNS Tumors (NCI-CONNECT) was developed to better understand tumor biology and patient outcomes for 12 selected brain and other central nervous system (CNS) tumor histologies that are rare in adults to improve approaches to care and treatment. The aim of this study was to determine the incidence, prevalence, and survival of these selected rare histologies.MethodsData from the Central Brain Tumor Registry of the United States (CBTRUS) from 2000 to 2014 were used to calculate average annual age-adjusted incidence rates (AAIR) per 100,000 population overall and by sex, race, ethnicity, and age. NCI's Surveillance, Epidemiology and End Results (SEER) data were used to calculate relative survival (RS) estimates. Point prevalence for 2014 was estimated using annual age-specific incidence and survival from CBTRUS and SEER, respectively.ResultsOverall AAIR was 1.47 per 100,000 for all 12 rare histologies combined, with the highest histology-specific incidence in oligodendrogliomas (AAIR=0.40/100,000). Overall, most histologies were more common in males, adults (age 40+), Whites, and non-Hispanics. Ependymomas were the most prevalent histology at 4.11 per 100,000; followed by oligodendrogliomas at 3.68 per 100,000. Relative survival at 1-, 5-, and 10-years was 82.3%, 64.0%, and 55.4%, respectively for all 12 selected brain and other CNS tumor types combined. Ependymomas had the highest RS (1-year=94.2%, 5-year=83.9%, 10-year=78.6%) and gliosarcomas had the lowest relative survival rate (1-year=42.5%, 5-year=5.6%, 10-year=2.9%) at all three time points.ConclusionsIncidence and prevalence of these rare brain and other CNS tumor histologies have not been previously reported. Along with survival, these data provide a statistical foundation to understand the impact of these cancers and provide important disease-specific data for the design of prospective clinical trials.
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