期刊
JOURNAL OF MAGNETIC RESONANCE
卷 306, 期 -, 页码 202-212出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2019.07.018
关键词
In-cell NMR; In vivo NMR; On-cell NMR; Whole-cell NMR; Metabolomics; Solid-state NMR; Dynamic nuclear polarization
资金
- ERC [647474]
- European Research Council (ERC) [647474] Funding Source: European Research Council (ERC)
Nuclear magnetic resonance (NMR) spectroscopy is a versatile tool for investigating cellular structures and their compositions. While in vivo and whole-cell NMR have a long tradition in cell-based approaches, high-resolution in-cell NMR spectroscopy is a new addition to these methods. In recent years, technological advancements in multiple areas provided converging benefits for cellular MR applications, especially in terms of robustness, reproducibility and physiological relevance. Here, we review the use of cellular NMR methods for drug discovery purposes in academia and industry. Specifically, we discuss how developments in NMR technologies such as miniaturized bioreactors and flow-probe perfusion systems have helped to consolidate NMR's role in cell-based drug discovery efforts. (C) 2019 The Author(s). Published by Elsevier Inc.
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