期刊
APPLIED RADIATION AND ISOTOPES
卷 107, 期 -, 页码 40-46出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2015.09.010
关键词
Fluorine-18; Vesicular acetylcholine transporter; Automation; Positron emission tomography; Clinical studies
类别
资金
- National Institutes of Health, United States [MH092797, NS061025, NS075527]
- Mallinckrodt Institute of Radiology Pilot Grant MIR [15-007]
Automated production of a promising radiopharmaceutical (-) - (1-(8-(2-[F-18]fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-piperidin-4-yl)(4-fluorophenyl)methanone ([18F] VAT) for the vesicular acetylcholine transporter(VAChT) was achieved using a two-step procedure in a current Good Manufacturing Practices fashion. The production of [F-18]VAT was accomplished in approximately 140 min, with radiochemical yield of similar to 15.0% (decay corrected), specific activity > 111 GBq/mu mol, radiochemical purity >99% and mass of VAT similar to 3.4 mu g/batch (n > 10). The radiopharmaceutical product meets all quality control criteria for human use, and is suitable for clinical PET studies of VAChT. (C) 2015 Elsevier Ltd. All rights reserved.
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