Biodistribution in rats and estimates of doses to humans from 64CuCl2, a potential theranostic tracer

The aim of this study was to obtain data on the biodistribution of (CuCl2)-Cu-64 in rats and to obtain estimates of the radiation doses to humans by extrapolating the animal data. MicroPET imaging and biodistribution studies were carried out with Wistar rats, and the doses were estimated with OLINDA/EXM. The lower large intestine wall was found to be the critical organ with an absorbed dose of 139 +/- 34 and 125 +/- 32 mu Gy/MBq for females and males, respectively. The corresponding effective doses were estimated as 47 +/- 4 and 39 +/- 4 mu Sv/MBq. (C) 2016 Elsevier Ltd. All rights reserved.