期刊
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
卷 41, 期 6, 页码 695-698出版社
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/apnm-2016-0016
关键词
lactate; skeletal muscle; PGC-1 alpha; PDK4; UCP3
资金
- Japan Society for the Promotion of Science [26750304]
- Yamaha Motor Foundation for Sports
- Grants-in-Aid for Scientific Research [26750304] Funding Source: KAKEN
To examine the potential role of lactate as a signalling molecule in skeletal muscle, we performed global gene expression analysis of the mouse gastrocnemius muscle, 3 h after lactate administration using the Affymetrix GeneChip system (Affymetrix, Santa Clara, Calif., USA). Among the top 15 genes with the largest fold change, increased expression of Ppargc1a, Pdk4, and Ucp3 was confirmed using real-time quantitative polymerase chain reaction. Our findings suggest that lactate serves as a signal for upregulating genes related to mitochondrial function.
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