期刊
JOURNAL OF CHEMICAL NEUROANATOMY
卷 98, 期 -, 页码 17-26出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchemneu.2019.03.002
关键词
Microtubule; Cerebral ischemia; Hippocampus; Epothilone D
资金
- National Natural Science Foundation of China [81871014]
Disruption of microtubule cytoskeleton plays an important role during the evolution of brain damage after transient cerebral ischemia. However, it is still unclear whether microtubule-stabilizing drugs such as epothilone D (EpoD) have a neuroprotective action against the ischemia-induced brain injury. This study examined the effects of pre- and postischemic treatment with different doses of EpoD on the microtubule damage and the delayed neuronal death in the hippocampal CA1 subfield on day 2 following reperfusion after 13-min global cerebral ischemia. Our results showed that systemic treatment with 0.5 mg/kg EpoD only slightly alleviated the microtubule disruption and the CAl neuronal death, while treatment with 3.0 mg/kg EpoD was not only ineffective against the CAl neuronal death, but also produced additional damage in the dentate gyrus in some ischemic rats. Since the pyramidal cells in the CAl subfield and the granule neurons in the dentate gyrus are known to be equipped with dynamically different microtubule systems, this finding indicates that the effects of microtubule-disrupting drugs may be unpredictably complicated in the central nervous system.
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