期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 40, 期 1, 页码 54-66出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X19861909
关键词
Amygdala; arterial spin labeling; cerebral blood flow; depression; family history; prediction
资金
- National Natural Science Foundation of China [81525014, 81871343]
- Jiangsu Provincial Key Research and Development Plan [BE2017698]
- Natural Science Foundation of Jiangsu Province [BK20171311]
- project of Jiangsu Provincial Health and Family Planning Commission [Q201605]
- project of young key teacher training [5524040001]
- project of Jiangsu Provincial young medical talents [QNRC2016832, QNRC2016460]
- six talent peaks project in Jiangsu Province [2016-WSW-125]
- 333 Project research projects in Jiangsu Province [BRA2016141]
- project of Zhenjiang social development [SH2017014]
Healthy first-degree relatives of patients with major depression are at an elevated risk of developing depression, and regional cerebral blood flow (CBF) alterations are observed in patients with depression. Therefore, in a 33-month follow-up study, we used arterial spin labeling-magnetic resonance imaging (ASL-MRI) to investigate quantitative CBF before and after the diagnosis of depression in healthy young adults with and without first-degree relatives with major depression (FH + and FH-, respectively). In cross-sectional and longitudinal CBF comparisons, CBF in the right amygdala was increased or decreased. Additionally, a significant correlation was observed between the altered CBF in the right amygdala and the scores on the 17-item Hamilton Depression Rating Scale (HDRS) in the FH + group. Furthermore, logistic regression and receiver operating characteristic curve analyses showed that increased CBF in the right amygdala at baseline predicted the subsequent onset of depression in the FH + group. Our results suggest that among healthy young adults with a familial risk of depression, those who exhibit increased CBF in the amygdala are susceptible to developing this disease.
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