期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 120, 期 9, 页码 14262-14273出版社
WILEY
DOI: 10.1002/jcb.28946
关键词
bone; crosstalk; muscle; myokines; osteoporosis; sarcopenia
资金
- National Natural Science Foundation of China [81772409]
The nature of muscle-bone crosstalk has been historically considered to be only mechanical, where the muscle is the load applier while bone provides the attachment sites. However, this dogma has been challenged with the emerging notion that bone and muscle act as secretory endocrine organs affect the function of each other. Biochemical crosstalk occurs through myokines such as myostatin, irisin, interleukin (IL)-6, IL-7, IL-15, insulin-like growth factor-1, fibroblast growth factor (FGF)-2, and beta-aminoisobutyric acid and through bone-derived factors including FGF23, prostaglandin E-2, transforming growth factor beta, osteocalcin, and sclerostin. Aside from the biochemical and mechanical interaction, additional factors including aging, circadian rhythm, nervous system network, nutrition intake, and exosomes also have effects on bone-muscle crosstalk. Here, we summarize the current research progress in the area, which may be conductive to identify potential novel therapies for the osteoporosis and sarcopenia, especially when they develop in parallel.
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