期刊
JOURNAL OF CELL BIOLOGY
卷 218, 期 8, 页码 2456-2469出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201903066
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资金
- National Defense Science and Engineering Graduate fellowship
- National Science Foundation
- National Institutes of Health National Cancer Institute grant [R37 CA214136]
In epithelial cancers, cells must invade through basement membranes (BMs) to metastasize. The BM, a thin layer of extracellular matrix underlying epithelial and endothelial tissues, is primarily composed of laminin and collagen IV and serves as a structural barrier to cancer cell invasion, intravasation, and extravasation. BM invasion has been thought to require protease degradation since cells, which are typically on the order of 10 mu m in size, are too large to squeeze through the nanometer-scale pores of the BM. However, recent studies point toward a more complex picture, with physical forces generated by cancer cells facilitating protease-independent BM invasion. Moreover, collective cell interactions, proliferation, cancer-associated fibroblasts, myoepithelial cells, and immune cells are all implicated in regulating BM invasion through physical forces. A comprehensive understanding of BM structure and mechanics and diverse modes of BM invasion may yield new strategies for blocking cancer progression and metastasis.
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