期刊
JOURNAL OF BIOPHOTONICS
卷 12, 期 9, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201800449
关键词
biofilms; chorioamnionitis; GBS; Group B Streptococcus; Raman spectroscopy; Streptococcus agalactiae
资金
- Department of Defense, Air Force of Scientific Research, National Defense Science and Engineering Graduate (NDSEG) Fellowship [32 CFR 168a]
- National Cancer Institute (Cooperative Human Tissue Network at Vanderbilt University)
- National Center for Advancing Translational Sciences [2 UL1 TR000445-06]
- National Institutes of Health [HD090061, HD081121]
- Office of Medical Research, Department of Veterans Affairs [IK2BX001701]
- Global Alliance to Prevent Prematurity and Stillbirth [1, 2]
- Vanderbilt Institute for Clinical and Translational Research [UL1 RR024975-01]
- VUMC Faculty Research Scholars Award [1]
Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is a major cause of chorioamnionitis and neonatal sepsis. This study evaluates Raman spectroscopy (RS) to identify spectral characteristics of infection and differentiate GBS from Escherichia coli and Staphylococcus aureus during ex vivo infection of human fetal membrane tissues. Unique spectral features were identified from colonies grown on agar and infected fetal membrane tissues. Multinomial logistic regression analysis accurately identified GBS infected tissues with 100.0% sensitivity and 88.9% specificity. Together, these findings support further investigation into the use of RS as an emerging microbiologic diagnostic tool and intrapartum screening test for GBS carriage.
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