期刊
JOURNAL OF APPLIED POLYMER SCIENCE
卷 136, 期 48, 页码 -出版社
WILEY
DOI: 10.1002/app.48234
关键词
biocompatibility; blood purification; hemodialysis; iron oxide nanoparticles; middle molecule uremic toxin; mixed matrix hollow fiber membranes
资金
- Ministry of Education Malaysia through Universiti Teknologi Malaysia [01G46, RUG 13H64]
- Ministry of Education Malaysia through HiCOE grant [4J206]
Middle molecule uremic toxins constitute to a quarter of uremic toxins present in human blood. In a condition where these uremic toxins accumulate in bloodstream due to renal failure, blood purification process using a high performance membrane is required. Here, we develop biocompatible mixed matrix membranes (MMMs) made up of polysulfone (PSf) and iron oxide nanoparticles (Fe2O3 NPs) with the focus to remove middle molecule uremic toxin effectively. The MMMs were evaluated in terms of their biocompatibility and separation performance. At higher Fe2O3 NPs loading, the MMM displayed a huge reduction of protein adsorption and platelet adhesion while maintaining normal blood coagulation time and acceptable complement activation. The optimized MMM exhibited high permeability (110.47 L m(-2) h(-1) bar(-1)), protein retention (99.9%) and demonstrated excellent clearance of urea (82%) and lysozyme (46.7%). The PSf/Fe2O3 MMM is proven to have promising attributes for hemodialysis application. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48234.
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