期刊
JOURNAL OF ANTIBIOTICS
卷 72, 期 10, 页码 775-778出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41429-019-0208-6
关键词
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资金
- Institute for Fermentation, Osaka (IFO), Japan
- JSPS KAKENHI [JP17K15250, JP15K18601]
- Kitasato University
A new N-cinnamoyl tripeptide, designated cipralphelin (1), was isolated from a cultured broth of Penicillium brevicompactum FKJ-0123 by physicochemical (PC) screening. Compound 1 was purified by silica gel and ODS column chromatography followed by preparative HPLC. The structure of 1 was determined as N-cinnamoyl-prolyl-alanyl-phenylalanine methyl ester by nuclear magnetic resonance and mass spectrometry analyses. The absolute configurations of three amino acids were determined by an advanced Marfey's method applied to the hydrolysate of 1. Compound 1 was evaluated for its cytotoxicity, anti-microbial activity, and ability to scavenge or quench reactive oxygen species (ROS) such as superoxide anion radicals, hydroxy radicals, and singlet oxygen. Compound 1 exhibited potent scavenging activity against hydroxy radicals.
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