期刊
JOURNAL OF ANTIBIOTICS
卷 72, 期 10, 页码 779-782出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41429-019-0206-8
关键词
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资金
- National Natural Science Foundation of China [21662012, 41866005]
- Program for Innovative Research Team in University [IRT-16R19]
- Innovation project of university students [cxcyxj2018009]
- Innovation project of Postgraduate [Hyb2018-26]
One new pentenoic acid derivative, named 1,1'-dioxine-2,2'-dipropionic acid (1) and a new natural product, named 2-methylacetate-3,5,6-trimethylpyrazine (2), along with six known compounds (3-8), were obtained from the Cladosporium sp. JS1-2, an endophytic fungus isolated from the mangrove Ceriops tagal collected in South China Sea. Their structures were elucidated by detailed analysis of comprehensive spectroscopic data, and the structure of 1 was further determined by X-ray diffraction analyses. C-13 NMR chemical shifts of structure 2 was further determined by GIAO based C-13 NMR chemical shifts calculations. Compounds 1-4 and 6 showed growth inhibition activities against newly hatched larvae of Helicoverpa armigera Hubner with the IC50 values ranging from 100 to 150 mu g ml(-1). Compounds 1, 2, 4, 6 and 7 showed moderate antibacterial activities against Staphylococcus aureus with the MIC values of 25.0, 12.5, 6.25, 1.25, and 6.25 mu g ml(-1), respectively.
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