期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 68, 期 4, 页码 1391-1400出版社
IOS PRESS
DOI: 10.3233/JAD-181177
关键词
Alzheimer's disease; amyloid-beta; infiltrating macrophages; Kupffer cells; monocytes; peripheral clearance
资金
- National Natural Science Foundation of China [81471415, 81801088]
- Research Foundation of Xi'an Medical University [12FZ28, 2017DOC14, 2017GJFY30]
- Natural Science Basic Research Plan in Shaanxi Province of China [2018JM7065, 18JK0673]
- Xi'an Medical University's key disciplines of molecular immunology
Aging societies have high incidence rates of Alzheimer's disease (AD). AD is diagnosed at later disease stages and has a poor prognosis, and effective drugs and treatments for AD are lacking. The molecular mechanism of AD is not clear, and current research focuses primarily on amyloid-beta (A beta) deposition and tau protein hyperphosphorylation. A beta deposition is the most frequently hypothesized initiating factor of AD, and A beta clearance during the pathogenesis of AD may be an optional strategy to suppress AD development. Monocytes play important roles in the peripheral clearance of A beta. Therefore, the present review summarizes our current knowledge of the potential roles of infiltrating macrophages, circulating monocytes, and Kupffer cells in the peripheral clearance of A beta in AD.
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