期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 144, 期 3, 页码 710-719出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2019.05.040
关键词
Atopic eczema; atopic dermatitis; natural history; epidemiology
资金
- Medical Research Council [G0000934]
- Wellcome Trust [068545/Z/02, 076113/B/04/Z]
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Human Genome Research Institute (NHGRI)
- Juvenile Diabetes Research Foundation International (JDRF)
- Juvenile Diabetes Research Foundation International
- Wellcome Trust
- National Institute for Health Research Cambridge Biomedical Research Centre
- Wellcome Trust Strategic Award [079895]
- European Commission Framework Programme 6 [018996]
- French Ministry of Research
- MRC centenary award
- National Institute of Child Health and Human Development (NICHD)
- [U01 DK062418]
- ESRC [ES/S008349/1, ES/M001660/1] Funding Source: UKRI
- MRC [MR/N01104X/2] Funding Source: UKRI
- Medical Research Council [HDR-9002, HDR-9006] Funding Source: researchfish
- National Institute for Health Research [NIHR/CS/010/014] Funding Source: researchfish
- Wellcome Trust [205039/Z/16/Z] Funding Source: researchfish
Background: Atopic eczema onset is described primarily in early childhood, and the frequency and characteristics of adult onset disease remain controversial. Objective: We sought to determine the proportion of subjects who report atopic eczema symptoms between birth and midadulthood and to examine demographic, immunologic, and genetic factors associated with period of symptom onset. Methods: We conducted a longitudinal study using data from 2 nationally representative community-based birth cohorts from the United Kingdom: the British Cohort Studies 1958 and 1970. Subjects were followed from birth through age 42 to 50 years. The primary outcome was the age period of self-reported atopic eczema symptom onset based on repeated measures of self reported atopic eczema at each survey wave. Results: The annual period prevalence of atopic eczema ranged from 5% to 15% in 2 cohorts of more than 17,000 participants each followed from birth through middle age. There was no clear trend in prevalence by age, and among adults reporting active atopic eczema during a given year, only 38% had symptom onset reported in childhood. When compared with subjects whose eczema started in childhood, those with adult onset disease were more likely to be women, from Scotland or Northern England, of lower childhood socioeconomic group, smokers in adulthood, and less likely to have a history of asthma. In a subanalysis using data from the 1958 cohort only, genetic mutations previously associated with atopic eczema, including filaggrin-null mutations, and allergen-specific IgE were more common among those with childhood-onset disease. Conclusion: Rates of self-reported atopic eczema remain high after childhood, and adult-onset atopic eczema has different risk factor associations than childhood-onset eczema.
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