期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 67, 期 28, 页码 8029-8034出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b03234
关键词
exopolysaccharide; levan; antiadhesive; enterotoxigenic Escherichia coli; Bacillus amyloliquefaciens
资金
- National Natural Science Foundation of China [31871785]
- Natural Science Foundation of Jiangsu Province, China [BK20181207]
- Program of Introducing Talents of Discipline to Universities (111 Project) [111-2-06]
- Fundamental Research Funds for the Central Universities [JUSRP21914]
A special levan-type exopolysaccharide (EPS) from Bacillus amyloliquefaciens JN4 with antiadhesive activity against enterotoxigenic Escherichia coli (ETEC) was purified and identified. Chemical analysis indicated that EPS-JN4 with a low molecular weight of 8 kDa is composed of fructose and glucose with a molar ratio of 46.1:1. Structural analysis clarified that EPS-JN4 contains a main chain of beta-(2,6)-linked Fruf residues and intensive branches of a single 2-linked Fruf at every six residues. Furthermore, the superior antiadhesive activity of EPS-JN4 against ETEC showed its potential usage as an antiadhesive agent for diarrhea prevention. EPS-JN4 is a specific type of levan family, for its small molecular size and intensive branches. The results expand the knowledge on structural types of levan and illustrate its potential as an antiadhesive agent for diarrhea prevention, which will be conducive to elucidate the relation between structure and function.
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