期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 67, 期 26, 页码 7297-7303出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b01245
关键词
agarobiose; agarooligosaccharides; anticariogenic; Streptococcus mutans; dental caries; agar; agarose; red macroalgae
资金
- National Research Foundation of Korea - Ministry of Science and Information and Communications Technology (MSIT) [NRF-2017R1A2B2005628, NRF-2018R1A4A1022589]
3,6-Anhydro-L-galactose (AHG) produced from agarose in red macroalgae was recently suggested as an anticariogenic sugar to replace widely used xylitol. However, the multi-step process for obtaining monomeric sugar AHG from agarose may be expensive. Generally, it is easier to obtain oligosaccharides than monosaccharides from polysaccharides. Therefore, a one-step process to obtain agarobiose (AB) from agarose was recently developed, and here, we suggest AB as a new anticariogenic agent, owing to its anticariogenic activity against Streptococcus mutans. Among AHG-containing oligosaccharides, AB, neoagarobiose (NAB), agarooligosaccharides (AOSs), and neoagarooligosaccharides (NAOSs), AB showed higher inhibitory activity than AOSs against the growth and lactic acid production of S. mutans; no such inhibitory activity was observed for NAB and NAOSs. This inhibitory effect of AB was comparable to the previously reported inhibitory activity of AHG against S. mutans. These results suggest that AB, which can be more economically and simply produced than AHG, may serve as an anticariogenic sugar.
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